autoantigens and autoantibodies in multiple sclerosis.
نویسندگان
چکیده
multiple sclerosis (ms) is an autoimmune disease characterized by recurrent episodes of demyelination and axonal lesion mediated by cd4+ t cells with a proinflammatory t helper (th)1 and th17 phenotypes, macrophages, and soluble inflammatory mediators. the overactive pro-inflammatory th1 cells and clonal expansion of b cells initiate an inflammatory cascade with several cellular and molecular immune components participating in ms pathogenic mechanisms. in this scenario, autoantibodies and autoantigens have a significant role in immunopathogenesis, diagnosis and therapeutic targets of ms. in this review, we try to introduce the autoantigens and autoantibodies and explain their roles in pathogenesis of ms.
منابع مشابه
Autoantigens and autoantibodies in multiple sclerosis.
Multiple sclerosis (MS) is an autoimmune disease characterized by recurrent episodes of demyelination and axonal lesion mediated by CD4+ T cells with a proinflammatory T helper (Th)1 and Th17 phenotypes, macrophages, and soluble inflammatory mediators. The overactive pro-inflammatory Th1 cells and clonal expansion of B cells initiate an inflammatory cascade with several cellular and molecular i...
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عنوان ژورنال:
iranian journal of allergy, asthma and immunologyجلد ۱۲، شماره ۴، صفحات ۲۹۲-۳۰۳
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